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A selective chemiresistive sensor for the cancer-related volatile organic compound hexanal by using molecularly imprinted polymers and multiwalled carbon nanotubes

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Abstract

A chemiresistive sensor is described for the lung cancer biomarker hexanal. A composite consisting of molecularly imprinted polymer nanoparticles and multiwalled carbon nanotubes was used in the sensor that is typically operated at a voltage of 4 V and is capable of selectively sensing gaseous hexanal at room temperature. It works in the 10 to 200 ppm concentration range and has a 10 ppm detection limit (at S/N = 3). The sensor signal recovers to a value close to its starting value without the need for heating even after exposure to relatively high levels of hexanal.

Schematic presentation of a chemiresistive sensor for detection of hexanal, a cancer biomarker. The hexanal-imprinted polymeric nanoparticles were synthesized, mixed with multiwalled carbon nanotubes and coated on the surface of an interdigitated electrode to produce a nanocomposite chemiresistor gas sensor for hexanal.

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Acknowledgements

Authors express their gratitude to Geoffrey Barrow for language revision and his valuable comments. We would like to thank Dr. Moslem Shojaee for sharing his experience with the experimental setup.

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Authors and Affiliations

  1. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Jalal Ale Ahmad Highway, Tehran, 14117, Iran

    Sajjad Janfaza & Maryam Nikkhah

  2. Department of Biomaterials, Faculty of Interdisciplinary Sciences, Tarbiat Modares University, Jalal Ale Ahmad Highway, Tehran, 14117, Iran

    Maryam Banan Nojavani

  3. Department of Analytical Chemistry, Faculty of Chemistry, University College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran

    Taher Alizadeh & Mohammad Reza Ganjali

  4. Department of Physics, Sharif University of Technology, P.O. Box 11155–9161, Tehran, Iran

    Ali Esfandiar

  5. Condensed Matter National Laboratory, Institute for Research in Fundamental Sciences, P.O. Box 1956838861, Tehran, Iran

    Ali Esfandiar

Authors
  1. Sajjad Janfaza
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  2. Maryam Banan Nojavani
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  3. Maryam Nikkhah
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  4. Taher Alizadeh
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  5. Ali Esfandiar
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  6. Mohammad Reza Ganjali
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Correspondence to Maryam Nikkhah.

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This study was funded by research council of Tarbiat Modares University.

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Sajjad Janfaza and Maryam Banan Nojavani are considered co-first authors.

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Janfaza, S., Banan Nojavani, M., Nikkhah, M. et al. A selective chemiresistive sensor for the cancer-related volatile organic compound hexanal by using molecularly imprinted polymers and multiwalled carbon nanotubes. Microchim Acta 186, 137 (2019). https://doi.org/10.1007/s00604-019-3241-z

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  • DOI: https://doi.org/10.1007/s00604-019-3241-z

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